| Identification | Back Directory | [Name]
3-[(aminocarbonyl)amino]alanine | [CAS]
585-23-9 | [Synonyms]
2-Amino-3-ureidopropanoic acid
3-[(aminocarbonyl)amino]alanine
(3S)-3-amino-3-ureido-propionic acid
(3S)-3-amino-3-(carbamoylamino)propanoic acid
3-[(Aminocarbonyl)amino]-2-aminopropionic acid
(3S)-3-(aminocarbonylamino)-3-azanyl-propanoic acid | [EINECS(EC#)]
209-550-8 | [Molecular Formula]
C4H9N3O3 | [MDL Number]
MFCD00078316 | [MOL File]
585-23-9.mol | [Molecular Weight]
147.13 |
| Hazard Information | Back Directory | [Description]
Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification. | [Uses]
Albizziin is an amino acid analog with activity as a competitive inhibitor of asparagine synthetase. Albizziin has been used to isolate Chinese hamster ovary cell mutants with altered levels of the target enzyme. Several mutational classes of albizziin can be distinguished based on cross-resistance to β-aspartic hydroxamic acid. Studies on asparagine synthetase have shown that resistance to albizziin may be associated with altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification[1]. | [References]
[1] Structure of albizziine [L(-)-2-amino-3-ureidopropionic acid], an amino acid from higher plants (Mimosaceae) |
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