| Hazard Information | Back Directory | [Description]
CRA-19156 is a potent HDAC8 inhibitor. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from lysines near the N termini of histones. This reaction promotes the condensation of chromatin, leading to repression of transcription. HDAC deregulation has been linked to several types of cancer, suggesting a potential use for HDAC inhibitors in oncology. | [Uses]
CRA-19156 is an active compound. | [References]
[1] Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues |
|
|