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ChemicalBook--->CAS DataBase List--->5746-24-7

5746-24-7

5746-24-7 Structure

5746-24-7 Structure
IdentificationBack Directory
[Name]

ketohypoglycin
[CAS]

5746-24-7
[Synonyms]

ketohypoglycin
Methylenecyclopropylpyruvate
Cyclopropanepropanoic acid, 2-methylene-α-oxo-
[Molecular Formula]

C7H8O3
[MOL File]

5746-24-7.mol
[Molecular Weight]

140.14
Hazard InformationBack Directory
[Description]

Ketohypoglycin has been used to study the inhibition of gluconeogenesis in isolated rat liver cells.
[Uses]

Methylenecyclopropylpyruvate (Ketohypoglycin) is an inhibitor for gluconeogenesis. Methylenecyclopropylpyruvate inhibits ketogenesis and affects the fatty acids metabolism. Methylenecyclopropylpyruvate may interfere with the mitochondrial β-oxidation pathway, affects the contents and composition of coenzyme A, and affects the glucose homeostasis[1].
[Definition]

ChEBI: Beta-(methylenecyclopropyl)pyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens has been replaced by a methylenecyclopropyl group. It has a role as a rat metabolite and a xenobiotic metabolite. It is a 2-oxo monocarboxylic acid, a member of cyclopropanes and an olefinic compound. It is functionally related to a pyruvic acid.
[References]

[1] Kean EA, et al., Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin). Biochem J. 1979 Sep 15;182(3):789-96. DOI:10.1042/bj1820789
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