| Identification | Back Directory | [Name]
5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- | [CAS]
56990-57-9 | [Synonyms]
NSC 87877
NSC 87877(free acid)
XGMFVZOKHBRUTL-QURGRASLSA-N
8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonicacid
5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
5-Quinolinesulfonicacid, 8-hydroxy-7-[2-(6-sulfo-2-naphthalenyl)diazenyl]-
(7e)-8-oxo-7-[(6-sulfonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonic Acid | [Molecular Formula]
C19H13N3O7S2 | [MDL Number]
MFCD09971104 | [MOL File]
56990-57-9.mol | [Molecular Weight]
459.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at +4°C | [solubility ]
≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic | [form ]
Powder | [color ]
Light brown to black |
| Hazard Information | Back Directory | [Uses]
NSC 87877 is an inhibitor of SHP2 and SHP1 protein tyrosine phosphatases | [Definition]
ChEBI: 8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid. | [Biological Activity]
Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC 50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. | [in vivo]
NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
| Animal Model: | Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3].
| | Dosage: | 30?mg/kg. | | Administration: | IP once daily for 15 days. | | Result: | Significantly inhibited NB tumor growth. |
| [storage]
Store at +4°C |
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