Identification | Back Directory | [Name]
Spiromustine | [CAS]
56605-16-4 | [Synonyms]
SHM NCI172112 NSC268497 NSC-172112 Spiromustine Spiromustard spirohydantoin mustard Spirohydantoin masturd Spiromustine USP/EP/BP 3-[2-[Bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione 3-[2-[bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-quinone 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[2-[bis(2-chloroethyl)amino]ethyl]- | [Molecular Formula]
C14H23Cl2N3O2 | [MDL Number]
MFCD00866539 | [MOL File]
56605-16-4.mol | [Molecular Weight]
336.26 |
Chemical Properties | Back Directory | [Melting point ]
125.5°C | [density ]
1.3876 (rough estimate) | [refractive index ]
1.6070 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.53±0.20(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
Antineoplastic. | [in vivo]
NCI172112 (Spirohydantoin mustard, SHM) might serve as a carrier to cross the blood brain barrier[1]. The cumulative excretion of radioactivity in the urine and faeces of rats after administration of [2-chloroethyl-U-14C]NCI172112 or [hydantoin-4-14C]NCI172112 ( 3.13 mg/kg. i.v.) is measured. Four hours after dosing, a significantly (P<0.005) greater amount of radioactivity has been excreted in the urine of rats treated with [hydantoin-14C]NCI172112 than with [ethyl-14C]NCI172112. However, by 24 h, approx.50% of dose is recovered in the urine with both labelled materials. Clearance of radioactivity in the faeces is slow, but, as for the renal excretion, is significantly greater for the hydantoin-14C moiety. No radioactivity is found in the expired air of a rat receiving a single dosing of [hydantoin-14C]NCI172112 and less than 1% is measured after administration of [ethyl-14C]NCI172112. Renal clearance of radioactivity is similar 4 h after administration of [14C]NCI172112 to rats with biliary cannulas, with 14.1±2.9 and 17.5±2.1% of the ethyl-14C and 34.5±2.5 and 33.1±6.3%, of the hydantoin-14C dose appearing in the urine after dosing with 3.13 and 6.25 mg/kg,
respectively. A difference in the 4 h urinary excretion of the two labels also is observed in dogs given [14C]NCI172112 (1 mg/kg, i.v.). The percentages of hydantoin-14C and ethyl-14C eliminated are 29.4±2.7% and 17.2±3.5%, respectively (P<0.05)[2]. |
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LGM Pharma
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1-(800)-881-8210 |
Website: |
www.lgmpharma.com |
Company Name: |
MedChemExpress
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021-58955995 |
Website: |
www.medchemexpress.com |
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