| Identification | Back Directory | [Name]
A26771B | [CAS]
56448-20-5 | [Synonyms]
A26771B
Reaxys ID: 1270041
Reaxys ID: 4720170
Antibiotic A-26771B
Succinic acid 1-[(3E,6S,16R)-16-methyl-2,5-dioxooxacyclohexadec-3-en-6-yl] ester
Succinic acid 1-[(3E,6S,16R)-2,5-dioxo-16-methyl-1-oxa-3-cyclohexadecen-6-yl] ester
5-O-(3-carboxypropionyl)-4-oxo-4,6,7,8,9,10,11,12,13,14,16-undecadeoxy-D-glycero-L-glycero-(E)-2-hexadecano-1,15-lactone | [Molecular Formula]
C20H30O7 | [MDL Number]
MFCD31692139 | [MOL File]
56448-20-5.mol |
| Hazard Information | Back Directory | [Description]
A 26771B is a macrolide antibiotic originally isolated from P. turbatum. It is active against S. aureus, S. faecalis, V. coli, M. gallisepticum, M. granularum, M. synoviae, M. hyosynoviae, M. hyopneumoniae, E. amylovora, P. multocida, and X. phaseoli bacteria (MICs = <0.78-50 μg/ml). A 26771B is active against various methicillin-resistant S. aureus (MRSA) strains (MICs = 6-16 μg/ml). A 26771B is also active against C. tropicalis, T. mentagrophytes, B. cinerea, C. ulmi, and V. albo-atrum fungi (MICs = 6.25-100 μg/ml). | [Uses]
A-26771B is an antibiotic can be obtained from Penicillium turbatum. A-26771B exhibits moderate antimicrobial activity against Gram-positive bacteria, mycoplasma, and fungi. A-26771B also inhibits potassium-dependent ATPase in rat liver mitochondria[1]. | [storage]
Store at -20°C | [References]
[1] Michel KH, et al. The isolation and structure elucidation of macrocyclic lactone antibiotic, A26771B. J Antibiot (Tokyo). 1977 Jul;30(7):571-5. DOI:10.7164/antibiotics.30.571 |
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