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ChemicalBook--->CAS DataBase List--->564479-79-4

564479-79-4

564479-79-4 Structure

564479-79-4 Structure
IdentificationBack Directory
[Name]

RXPA 380
[CAS]

564479-79-4
[Synonyms]

RXPA 380
IMPJIKIXNAGRCR-SFOGZRFBSA-N
[Molecular Formula]

C33H36N3O7P
[MOL File]

564479-79-4.mol
[Molecular Weight]

617.63
Chemical PropertiesBack Directory
[Boiling point ]

996.6±65.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[pka]

3.05±0.40(Predicted)
Hazard InformationBack Directory
[Description]

RXPA380 is a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain.
[Uses]

RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM[1].
[in vivo]

RXPA 380 (0.9-30 mg/kg; i.v.; once) inhibits ACE activity in mice[1].

Animal Model:Male C57BL6/J mice[1]
Dosage:0.9, 3, 10, and 30 mg/kg
Administration:Intravenous infuse for 30 minutes
Result:Induced a dose-dependent decrease of the Ang II/Ang I ratio. Blocked the cleavage of exogenously administered bradykinin.
[References]

[1] Georgiadis D, et al. Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors. Circ Res. 2003 Jul 25;93(2):148-54. DOI:10.1161/01.RES.0000081593.33848.FC
564479-79-4 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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