823-76-7

56077-28-2

Step 1. Cyclohexyl ketone (0.30 mL, 2.4 mmol) was dissolved in pre-cooled methanol (3.0 mL, 74 mmol) in an ice bath. Subsequently, bromine (0.38 g, 2.4 mmol) was added slowly and dropwise to this solution. The reaction mixture was stirred for 2 hr. then water (3.0 mL) was added and stirring was continued for 4 hr. Upon completion of the reaction, the reaction mixture was extracted with a solvent mixture of ethyl acetate: hexane (3:1). The organic layers were combined and washed sequentially with water, saturated potassium carbonate solution and brine, then dried with magnesium sulfate. After concentration under reduced pressure, 2-bromo-1-cyclohexylethanone was obtained as a clear oil (0.49 g, 100%). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 3.96 (s, 2H), 2.86-2.55 (m, 1H), 2.24-1.08 (m, 10H).