| Identification | Back Directory | [Name]
Mannomustine | [CAS]
551-74-6 | [Synonyms]
NSC9698
NSC-9698
NSC 9698
Degranol
Degranol chinoin
MANNOMUSTINEHYDROCHLORIDE
MANNOUMUSINEDIHYDROCHLORIDE
Mannomustine dihydrochloride
1,6-Bis[(chloroethyl)amino]-1,6-desoxy-D-mannitol dihydrochloride
1,6-Bis[(chloroethyl)amino]-1,6-dideoxy-D-mannite dihydrochloride
1,6-Dideoxy-1,6-di[(2-chloroethyl)amino]-D-mannitol dihydrochloride
1,6-Bis-(.beta.-chloraethylamino)-1,6-desoxy-D-mannit-dichlorhydrat
D-Mannitol, 1,6-bis(2-chloroethylamino)-1,6-dideoxy-, dihydrochloride
D-Mannitol, 1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride | [Molecular Formula]
C10H22Cl2N2O4.2ClH | [MDL Number]
MFCD01741284 | [MOL File]
551-74-6.mol | [Molecular Weight]
378.122 |
| Safety Data | Back Directory | [Safety Profile]
Poison by intravenous,
subcutaneous, and parented routes.
Experimental reproductive effects.
Questionable carcinogen with experimental
carcinogenic and neoplastigenic data. Human mutation data reported. A drug used
for the treatment of malignant neoplasms.
When heated to decomposition it emits very
toxic fumes of HCl and NOx. See also
MANNOMUSTINE. | [Toxicity]
LD50 i.v. in rats: 56 mg/kg (Scherf) |
| Hazard Information | Back Directory | [Uses]
Mannomustine dihydrochloride is an alkylating agent with antineoplastic activity. Mannomustine dihydrochloride causes severe bone marrow depression. Mannomustine dihydrochloride is a powerful vesicant. | [Definition]
ChEBI:Mannomustine dihydrochloride is an organic molecular entity. | [References]
[1] Some effects of 1-methyl-2-p-(isopropyl-carbamoyl)-benzyl-hydrazine and mannomustine on the metabolism of human erythrocytes in vitro |
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