| Identification | Back Directory | [Name]
1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride | [CAS]
5424-37-3 | [Synonyms]
Surfen
Surfen (NSC-12155)
Surfen dihydrochloride
NSC-12155 (surfen hydrate)
Aminoquinuride hydrochloride
Aminokinuride dihydrochloride
Aminoquinuride dihydrochloride
Aminoquincarbamide dihydrochloride
1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride | [EINECS(EC#)]
226-566-0 | [Molecular Formula]
C21H22Cl2N6O | [MDL Number]
MFCD01676891 | [MOL File]
5424-37-3.mol | [Molecular Weight]
445.345 |
| Hazard Information | Back Directory | [Uses]
Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1]. | [IC 50]
FGFR2: 5 μM (IC50); HSV-1 | [storage]
Store at -20°C | [References]
[1] Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. DOI:10.1073/pnas.0805862105 |
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