| Identification | Back Directory | [Name]
1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID | [CAS]
5382-49-0 | [Synonyms]
Tetrahydroquinoline-6-carboxylic acid
6-Carboxy-1,2,3,4-tetrahydroquinoline
1,2,3,4-Tetrahydroquinoline-6-carboxylic acid
1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID
6-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-
1,2,3,4-Tetrahydroquinoline-6-carboxylic acid 95+% | [Molecular Formula]
C10H11NO2 | [MDL Number]
MFCD00957087 | [MOL File]
5382-49-0.mol | [Molecular Weight]
177.2 |
| Chemical Properties | Back Directory | [Melting point ]
168 °C | [Boiling point ]
382.6±31.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
4.96±0.20(Predicted) | [Appearance]
Off-white to yellow Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 39, p. 2044, 1974 DOI: 10.1021/jo00928a014 | [Synthesis]
GENERAL STEPS: 1-Acetyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile (50 mmol) was dissolved in 8 M hydrochloric acid (150 mL) and the reaction was carried out at reflux for 18 hours. Upon completion of the reaction, the mixture was cooled and the pH was adjusted with sodium hydroxide solution to about 3. The precipitated 1,2,3,4-tetrahydroquinoline-6-carboxylic acid was separated by filtration, washed with water and dried. Yield: 61%.1H NMR (D6-DMSO) δ: 1.79 (m, 2H), 2.68 (m, 2H), 3.23 (m, 2H), 5.45 (br, 1H), 6.48 (d, 1H), 7.45-7.50 (m, 2H). | [References]
[1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 31-32 |
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