| Identification | Back Directory | [Name]
2-Chloro-6-fluoroanisole | [CAS]
53145-38-3 | [Synonyms]
2-chloro-6-fluorobenzoether
1-Chloro-3-fluoro-2-Methoxybenzene
Benzene, 1-chloro-3-fluoro-2-methoxy-
2-Chloro-6-fluoroanisole ISO 9001：2015 REACH
1-Chloro-3-fluoro-2-methoxybenzene, 2-Chloro-6-fluorophenyl methyl ether | [Molecular Formula]
C7H6ClFO | [MDL Number]
MFCD01631573 | [MOL File]
53145-38-3.mol | [Molecular Weight]
160.58 |
| Chemical Properties | Back Directory | [Boiling point ]
186.4±20.0 °C(Predicted) | [density ]
1.239±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Benzene (Slightly), Chloroform, Methanol (Slightly) | [form ]
Oil | [color ]
Clear Colourless |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Synthesis]
GENERAL STEPS: Iodomethane (850 μL, 13.646 mmol) and potassium carbonate (943 mg, 6.824 mmol) were sequentially added to a solution of tetrahydrofuran (10 mL) containing 2-chloro-6-fluorophenol (1.0 g, 6.824 mmol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was transferred to a partition funnel and extracted with ether (50 mL) and water (50 mL) by partition. The organic phase was separated and washed with water (2 x 20 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-chloro-6-fluoroanisole as a colorless liquid in 94% yield (1.03 g).1H NMR (400 MHz, CD3OD) δ: 3.90-3.91 (s, 3H), 7.01-7.12 (m, 2H), 7.18-7.21 (m, 1H). | [References]
[1] Patent: WO2007/34325, 2007, A1. Location in patent: Page/Page column 47 |
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