| Identification | Back Directory | [Name]
METHYL 3-CHLOROPHENYLACETATE | [CAS]
53088-68-9 | [Synonyms]
Methyl3-chlorophenylacetat
METHYL 3-CHLOROPHENYLACETATE
Methyle3-chlorophenylacetate
Methyl 2-(3-chlorophenyl)acetate
Methyl 3-chlorophenylacetate,99%
Methyl 3-chlorophenylacetate,98%
Methyl 3-chlorophenylacetate, 98% 25GR
(3-CHLORO-PHENYL)-ACETIC ACID METHYL ESTER | [Molecular Formula]
C9H9ClO2 | [MDL Number]
MFCD00800679 | [MOL File]
53088-68-9.mol | [Molecular Weight]
184.62 |
| Chemical Properties | Back Directory | [Appearance]
clear slightly yellowish liquid | [Boiling point ]
120-121℃ (9 Torr) | [density ]
1.197±0.06 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.5225-1.5245
| [Fp ]
108.8±15.8℃ | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Liquid | [color ]
Clear colorless to light yellow |
| Hazard Information | Back Directory | [Chemical Properties]
clear slightly yellowish liquid | [Synthesis]
GENERAL METHOD: Thionyl chloride (1.06 mL, 14.63 mmol) was added slowly and dropwise to a solution of 3-chlorophenylacetic acid (1 g, 4.877 mmol) in methanol (10 mL) at 0 °C. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in a solvent mixture of ethyl acetate and water. The aqueous phase was extracted with ethyl acetate and the combined organic phases were washed with aqueous sodium bicarbonate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl m-chlorophenylacetate (6a-f). | [References]
[1] Tetrahedron, 1997, vol. 53, # 38, p. 13149 - 13164
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 13, p. 2843 - 2866
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 17, p. 2701 - 2706
[4] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 4, p. 1679 - 1693
[5] Tetrahedron Letters, 2003, vol. 44, # 2, p. 331 - 334 |
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