| Identification | Back Directory | [Name]
3-(4-methoxyphenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | [CAS]
52348-60-4 | [Synonyms]
CCT 039838
KDM4C-IN-1
3-(4-methoxyphenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 3-(4-methoxyphenyl)-1,6-dimethyl- | [Molecular Formula]
C14H13N5O3 | [MOL File]
52348-60-4.mol | [Molecular Weight]
299.28 |
| Chemical Properties | Back Directory | [Melting point ]
244 °C (decomp) | [Boiling point ]
415.3±47.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-2.92±0.20(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
KDM4C-IN-1 (Compound 4d) is a potent KDM4C inhibitor with an IC50 of 8 nM. KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells with IC50s of 0.8 μM and 1.1 μM, respectively[1]. | [IC 50]
KDM4 | [References]
[1] Vatroslav Letfus, et al. Rational design, synthesis and biological profiling of new KDM4C inhibitors. Bioorg Med Chem. 2020 Jan 1;28(1):115128. DOI:10.1016/j.bmc.2019.115128 |
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