| Identification | Back Directory | [Name]
ethyl 6-chloropyrimidine-4-carboxylate | [CAS]
51940-63-7 | [Synonyms]
Ethyl 6-chloropyriMidine-...
Ethyl 4-chloro-6-pyrimidinecarboxylate
ethyl 6-chloropyrimidine-4-carboxylate
6-Chloro-4-pyriMidinecarboxylic acid ethyl ester
6-Chloro-pyriMidine-4-carboxylic acid ethyl ester
6-chloro-4-Pyrimidine carbocylic acid ethyl ester
4-PyriMidinecarboxylic acid, 6-chloro-, ethyl ester | [Molecular Formula]
C7H7ClN2O2 | [MDL Number]
MFCD12756023 | [MOL File]
51940-63-7.mol | [Molecular Weight]
186.596 |
| Chemical Properties | Back Directory | [Boiling point ]
284.5±20.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-2.89±0.17(Predicted) | [Appearance]
Off-white to light brown Solid | [CAS DataBase Reference]
51940-63-7 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 6-Chloropyrimidine-4-carbonyl chloride (1.0 g, 5.65 mmol) was mixed with ethanol (0.4 mL, 6.94 mmol) in 30 mL of dichloromethane and the reaction was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The product ethyl 6-chloropyrimidine-4-carboxylate was obtained in a yield of 1.0 g, which was 95% of the theoretical value. The product was analyzed by ESI-MS, m/z = 187/189 ([M + H]+), and the Rf value of thin layer chromatography (silica gel plate) was 0.85 (unfolding agent: EtOAc). | [References]
[1] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 39
[2] Patent: US2011/195954, 2011, A1. Location in patent: Page/Page column 79 |
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