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ChemicalBook--->CAS DataBase List--->51638-90-5

51638-90-5

51638-90-5 Structure

51638-90-5 Structure
IdentificationBack Directory
[Name]

16-phenoxy tetranor Prostaglandin F2α methyl ester
[CAS]

51638-90-5
[Synonyms]

16-phenoxy tetranor Prostaglandin F2α methyl ester
16-phenoxy tetranor Prostaglandin F2.alpha. methyl ester
16-phenoxy tetranor Prostaglandin F2α methyl ester Exclusive
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]-, methyl ester, (5Z)-
[Molecular Formula]

C23H32O6
[MDL Number]

MFCD18427959
[MOL File]

51638-90-5.mol
[Molecular Weight]

404.5
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): .5 mg/ml
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07,GHS08
[Signal word ]

Danger
[Hazard statements ]

H225-H319-H360
[Precautionary statements ]

P201-P202-P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P308+P313-P337+P313-P370+P378-P403+P235-P405-P501
Hazard InformationBack Directory
[Description]

Prostaglandin F (PGF) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F (16-phenoxy tetranor PGF) is a metabolically stable form of PGF containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF. 16-phenoxy tetranor PGF methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
[Uses]

16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable form of Prostaglandin F2α that can binds to FP receptor. 16-Phenoxy tetranor Prostaglandin F2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid[1].
[storage]

Store at -20°C
[References]

[1] M Hayashi, Prostaglandin analogues possessing antinidatory effects. 2. Modification of the alpha chain. J Med Chem. 1980 May;23(5):525-35. DOI:10.1021/jm00179a011
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