| Identification | Back Directory | [Name]
Cimetropium bromide | [CAS]
51598-60-8 | [Synonyms]
da3177
Cimetropium
DA-3177：Alginor
Cimetropiumbromid
Cimetronin bromide
CIMETROPIUM BROMIDE
N-Cyclopropvlmethylscopolamine bromide
(7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane bromide | [EINECS(EC#)]
641-412-6 | [Molecular Formula]
C21H28BrNO4 | [MDL Number]
MFCD00865226 | [MOL File]
51598-60-8.mol | [Molecular Weight]
438.36 |
| Chemical Properties | Back Directory | [Melting point ]
174° | [alpha ]
D20 -18.3° (c = 3) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White |
| Hazard Information | Back Directory | [Description]
Cimetropium bromide is an analog of the anticholinergics methscopolamine,
ipratropium and oxitropium bromides. It is reported to be useful in the treatment
of increased tone and motility of the gastrointestinal, biliary and urogenital tracts. | [Originator]
deAngelin (Italy) | [Uses]
Cimetropium Bromide is a new antimuscarinic drug used for long-term treatment of irritable bowel syndrome. | [Brand name]
ALGINOR | [in vivo]
When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID50 of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension[1]. | [storage]
Store at -20°C |
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