| Identification | Back Directory | [Name]
ISO-OMPA | [CAS]
513-00-8 | [Synonyms]
DPDA
ISO-OMPA
Dipropyldiphosphoramide
tetraisopropylpyrophosphamide
TETRAISOPROPYL PYROPHOS-PHORAMIDE
Tetraisopropylpyrophosphoramide,~96%
TETRA[MONOISOPROPYL]-PYROPHOSPHORTETRAMIDE
Oxybis[bis(isopropylamino)phosphine oxide]
N,N',N'',N'''-tetraisopropyldiphosphoramide
Diphosphoramide, N,N,N,N-tetrakis(1-methylethyl)-
iso-OMPA, Tetra(monoisopropyl)pyrophosphortetramide
Tetraisopropyl pyrophosphoramide butyrylcholinesterase inhibitor
[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]-isopropyl-amine
N-[bis(propan-2-ylamino)phosphoryloxy-(propan-2-ylamino)phosphoryl]propan-2-amine
Tetraisopropyl pyrophosphoramide,Tetra(monoisopropyl)pyrophosphortetramide, iso-OMPA | [EINECS(EC#)]
208-149-5 | [Molecular Formula]
C12H32N4O3P2 | [MDL Number]
MFCD00048272 | [MOL File]
513-00-8.mol | [Molecular Weight]
342.36 |
| Hazard Information | Back Directory | [Uses]
Tetraisopropyl pyrophosphoramide has been used:
- as a butyrylcholinesterase inhibitor to determine the proportions of butyrylcholinesterase (BChE) in cat and tiger plasma
- to inhibit wild-type BChE in acetylcholinesterase assay
- to selectively block the enzymatic activity of AChE
| [Definition]
ChEBI: Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)- is a phosphoramide. | [Biochem/physiol Actions]
Selective inhibitor of butyrylcholinesterase | [in vivo]
Iso-OMPA (0.6-1.9 mg/kg, subcutaneous injection, single dose) enhances soman toxicity in rats but has no effect on mice[3]. | Animal Model: | Mouse and rat[3] | | Dosage: | 0.6, 1.9 mg/kg; single dose | | Administration: | Subcutaneous injection (s.c.) | | Result: | Caused rat plasma CarbE activity to be only slightly inhibited by lower doses and significantly inhibited by higher doses. CarbE activity in mice was not inhibited. |
| [IC 50]
BuChE |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|