| Identification | Back Directory | [Name]
2'-METHYLPHENACYL BROMIDE | [CAS]
51012-65-8 | [Synonyms]
AKOS BBS-00004007
Zolpidem Impurity 21
2-(Bromoacetyl)toluene
2-METHYLPHENACYL BROMIDE
2'-METHYLPHENACYL BROMIDE
2-Methyl phenycyl Bromide
2-Bromo-1-o-tolyl-ethanone
2-bromo-2-methylacetophenone
Zolpidem tartrate Impurity 15
2-Bromo-1-(o-tolyl)ethan-1-one
2-Bromo-2'-methylacetophenone >
2-Bromo-2'-methylacetophenone,98%
2-bromo-1-(2-methylphenyl)ethanone
Ethanone, 2-bromo-1-(2-methylphenyl)-
2-Bromo-2'-methylacetophenone, 2-Bromo-1-(2-methylphenyl)ethan-1-one, 2-Bromo-1-(o-tolyl)ethan-1-one | [Molecular Formula]
C9H9BrO | [MDL Number]
MFCD04038955 | [MOL File]
51012-65-8.mol | [Molecular Weight]
213.07 |
| Chemical Properties | Back Directory | [Boiling point ]
82 | [density ]
1.416±0.06 g/cm3(Predicted) | [refractive index ]
1.5790 to 1.5830 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
clear liquid | [color ]
Light yellow to Yellow to Orange | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Lachrymatory |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [RIDADR ]
UN 2810 6.1/PG III | [Hazard Note ]
Irritant/Lachrymator | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
2914790090 |
| Hazard Information | Back Directory | [Uses]
2-Bromo-2'-methylacetophenone is an aromatic building block for proteomics research. | [Synthesis]
Example 6 Preparation of 2-bromo-1-o-tolylacetophenone (I15): 2-methylbenzoyl chloride (169 μL, 1.29 mmol) was dissolved in anhydrous acetonitrile (5 mL) under nitrogen protection and cooled to 0°C. Subsequently, (diazomethyl)-trimethylsilane (1.94 mL, 3.88 mmol, 2 M hexane solution) was slowly added. The reaction mixture was stirred at room temperature for 15 h. The reaction mixture was again cooled to 0 °C and 48% hydrobromic acid (512 μL, 4.53 mmol) was slowly added. The reaction mixture was continued to be stirred at room temperature for 3 hours. After completion of the reaction, the organic layer was separated by adding ethyl acetate (EtOAc) and water for extraction. The aqueous phase was neutralized with 1 M sodium hydroxide (NaOH) and extracted again with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford 2-bromo-1-o-toluene ethanone (250 mg, 91% yield). The intermediate could be used for subsequent reactions without further purification.1H NMR (300 MHz, DMSO-d6) δ ppm: 7.82-7.91 (m, 1H), 7.45-7.52 (m, 1H), 7.25-7.40 (m, 2H), 4.86 (s, 2H), 2.41 (s, 3H). | [References]
[1] Patent: US2011/311458, 2011, A1
[2] Patent: WO2011/161018, 2011, A1. Location in patent: Page/Page column 35 |
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