| Identification | Back Directory | [Name]
NIDA-41020 | [CAS]
502486-89-7 | [Synonyms]
NIDA-41020 >=97% (HPLC), solid
1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-1-piperidinyl-
N-(Piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide | [Molecular Formula]
C23H24Cl2N4O2 | [MDL Number]
MFCD08277026 | [MOL File]
502486-89-7.mol | [Molecular Weight]
459.37 |
| Hazard Information | Back Directory | [Uses]
NIDA 41020 is an analog of rimonabant, which is a CB1 cannabinoic receptor antagonist that diminishes the behavioral effects of opiates and nicotine. | [Biochem/physiol Actions]
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively]. | [IC 50]
CB1: 4.1 nM (Ki) | [storage]
Store at RT |
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