| Identification | Back Directory | [Name]
(S)-GNA-U-phosphoramidite | [CAS]
494784-15-5 | [Synonyms]
(S)-GNA-U-phosphoramidite
U-(S)-GNA phosphoramidite
Phosphoramidous acid, bis(1-methylethyl)-, (1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]ethyl 2-cyanoethyl ester (9CI) | [Molecular Formula]
C37H45N4O7P | [MOL File]
494784-15-5.mol | [Molecular Weight]
688.75 |
| Hazard Information | Back Directory | [Uses]
(S)-GNA-U-phosphoramidite is a monophosphate nucleoside similar to DNA or RNA but differing in the composition of its sugar-phosphodiester backbone, using propylene glycol in place of ribose or deoxyribose. | [References]
[1] Mark K Schlegel, et al. Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic Acids Res. 2021 Nov 8;49(19):10851-10867. DOI:10.1093/nar/gkab916 |
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