| Identification | Back Directory | [Name]
INNO-206 HCl salt/INNO206 HCl salt | [CAS]
480998-12-7 | [Synonyms]
INNO-206 HCI
INNO-206 HCL
Aldoxorubicin·HCl
INNO-206 hydrochloride
MC-DOXHZN hydrochloride
INNO-206 monohydrochloride
Aldoxorubicin Hydrochloride
INNO-206 HCl salt/INNO206 HCl salt
Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride
2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide monohydrochloride | [Molecular Formula]
C37H42N4O13.HCl | [MOL File]
480998-12-7.mol | [Molecular Weight]
787.22 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, sealed storage, away from moisture and light | [solubility ]
DMSO : 25 mg/mL (31.76 mM; Need ultrasonic)| | [form ]
A solid | [color ]
Brown to reddish brown | [Water Solubility ]
Water : 12.5 mg/mL (15.88 mM; ultrasonic and warming and heat to 60°C) |
| Hazard Information | Back Directory | [Uses]
MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties[1]. | [IC 50]
Topoisomerase II; Daunorubicins/Doxorubicins | [storage]
Store at -20°C, sealed storage, away from moisture and light | [References]
[1] Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug Delivery Journal, 2008, 2, 77-85.
[2] Inoh K, et al. Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug[J]. Japanese journal of clinical oncology, 2006, 36(4): 207-211. DOI:10.1093/jjco/hyl004 |
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