| Identification | Back Directory | [Name]
GGTI-2166 | [CAS]
478908-51-9 | [Synonyms]
GGTI-2166
L-Leucine, N-[[5-[(1H-imidazol-5-ylmethyl)amino]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester | [Molecular Formula]
C25H30N4O3 | [MOL File]
478908-51-9.mol | [Molecular Weight]
434.53 |
| Hazard Information | Back Directory | [Description]
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. |
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