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ChemicalBook--->CAS DataBase List--->477865-59-1

477865-59-1

477865-59-1 Structure

477865-59-1 Structure
IdentificationBack Directory
[Name]

N-(7-[1-(4-CHLORO-2-METHYLPHENOXY)ETHYL][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)-N'-METHOXYIMINOFORMAMIDE
[CAS]

477865-59-1
[Synonyms]

CMTPMF
CM-TPMF
CM TPMF
N-(7-[1-(4-CHLORO-2-METHYLPHENOXY)ETHYL][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)-N'-METHOXYIMINOFORMAMIDE
(E)-N-{7-[1-(4-chloro-2-methylphenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-methoxymethanimidamide
[Molecular Formula]

C16H17ClN6O2
[MDL Number]

MFCD00243642
[MOL File]

477865-59-1.mol
[Molecular Weight]

360.8
Chemical PropertiesBack Directory
[density ]

1.39±0.1 g/cm3(Predicted)
[pka]

1.55±0.30(Predicted)
Hazard InformationBack Directory
[Description]

CM-TPMF is a subtype-selective activator of K(Ca)2.1. The K(Ca)2.1 selectivity of (-)-CM-TPMF depends critically on Ser293 as revealed by loss- and gain-of-function mutations.
[Uses]

CM-TPMF is a K(Ca)2 channel modulator with selective activation and inhibition of K(Ca)2.1 subtypes. CM-TPMF can act on K(Ca)2.1 channels as an activator or inhibitor, and its activity is affected by the stereochemical structure. It can be used to study the physiological or pathophysiological effects of K(Ca)2.1 channels.
[References]

[1] Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype DOI:10.1124/mol.111.074252
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