| Identification | Back Directory | [Name]
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- | [CAS]
4765-59-7 | [Synonyms]
2-(4-Nitrophenyl)quinazolin-4(1H)-one
4(3H)-Quinazolinone, 2-(4-nitrophenyl)-
4(1H)-Quinazolinone, 2-(4-nitrophenyl)- | [Molecular Formula]
C14H9N3O3 | [MDL Number]
MFCD28157558 | [MOL File]
4765-59-7.mol | [Molecular Weight]
267.24 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [Boiling point ]
479.8±47.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5?+-.0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1]. | [References]
[1] Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27. DOI:10.1016/j.ejmech.2016.04.041 |
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