| Identification | Back Directory | [Name]
p38-α MAPK-IN-1 | [CAS]
443913-15-3 | [Synonyms]
MAPK-IN-1
p38-α MAPK-IN-1
MAPK14 INHIBITOR
p38-α MAPK inhibitor 1
p38-α MAPK inhibitor 1
Inhibitor,inhibit,p-38-α MAPK-IN-1,Autophagy,p38α MAPKIN1,p38 MAPK,p38 α MAPK IN 1
Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]phenyl]- | [Molecular Formula]
C27H35N5O3 | [MDL Number]
MFCD30533549 | [MOL File]
443913-15-3.mol | [Molecular Weight]
477.6 |
| Chemical Properties | Back Directory | [Boiling point ]
566.2±50.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (209.38 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
13.76±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1]. | [References]
[1] Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53(1):357-67. DOI:10.1021/jm901297e |
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