| Identification | Back Directory | [Name]
2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) | [CAS]
4330-21-6 | [Synonyms]
NSC 148837
Hoffer's chlorosugar
Hoffer's alpha-chlorosugar
Hoffer's Chlorosugar (~90%)
3,5-bis(toluoyl)-2-deoxyribosyl chloride
1-CHLORO-3,5-BIS[O-(4-TOLUOYL)]-2-DEOXYRIBOSE
3,5-di-O-(P-toluyl)-2-deoxy-D-*ribofuranosyl chlo
1-Chloro-2-deoxy-3,5-di-O-toluoyl-a-D-ribofuranose
1-Chloro-2-deoxy-3,5-di-O-p-toluoyl-alpha-D-ribose
1-Chloro-3,5-di-O-toluoyl-2-deoxy-a-D-ribofuranose
3,5-DI-O-(P-TOLUYL)-2-DEOXY-D-*RIBOFURAN OSYL CHLORI
3,5-Di-O-p-toluyl-2-deoxy-a-D-ribofuranosyl chloride
1-CHLORO-3,5-DI-O-TOLUOYL-2-DEOXY-ALPHA-D-RIBOFURANOSE
1-α-Chloro-3,5-di-O-(4-toluoyl) -2-deoxy-D-ribofuranose
3-O,5-O-Di-p-toluoyl-2-deoxy-α-D-ribofuranosyl chloride
1-Chloro-3-O,5-O-di-p-toluoyl-1,2-dideoxy-D-ribofuranose
3,5-DI-O-(P-TOLUYL)-2-DEOXY-ALPHA-D-RIBOFURANOSYL CHLORIDE
1-Chloro-2-deoxy-3,5-di-O-(4-toluoyl)-alpha-D-ribofuranose
3,5-DI-O-(P-TOLUYL)-2-DEOXY-D-RIBOFURANOSYL CHLORIDE, >95%
2-deoxydi(p-toluoyl)-alpha-D-erythro-pentofuranosyl chloride
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride
3-O,5-O-Bis(4-methylbenzoyl)-2-deoxy-α-D-ribofuranosyl chloride
3-O,5-O-Di-p-toluoyl-2-deoxy-α-D-erythro-pentofuranosyl chloride
2-Deoxy-3,5-O-di-p-toluoyl-alpha-D-erythro-pentofuranosyl Chloride
2-Deoxy-3,5-di-O-p-toluoyl-alpha-D-erythro-pentofuranosyl chloride
a-D-erythro-Pentofuranosylchloride, 2-deoxy-, 3,5-bis(4-methylbenzoate
α-D-erythro-Pentofuranosylchloride, 2-deoxy-, 3,5-bis(4-Methylbenzoate)
2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate)
2-Deoxy-3-O,5-O-bis(4-methylbenzoyl)-α-D-erythro-pentofuranosyl chloride
3-O,5-O-Bis(4-methylbenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl chloride
.alpha.-D-erythro-Pentofuranosyl chloride, 2-deoxy-, bis(4-methylbenzoate)
1-Chloro-3-O,5-O-bis(4-methylbenzoyl)-1,2-dideoxy-α-D-erythro-pentofuranose
[(2R,3S,5R)-5-chloro-3-(4-methylbenzoyloxy)oxolan-2-yl]methyl 4-methylbenzoate
2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) USP/EP/BP
(2R,3S,5R)-5-Chloro-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate | [EINECS(EC#)]
224-367-3 | [Molecular Formula]
C21H21ClO5 | [MDL Number]
MFCD00079148 | [MOL File]
4330-21-6.mol | [Molecular Weight]
388.84 |
| Chemical Properties | Back Directory | [Melting point ]
117-119 °C | [Boiling point ]
518.4±50.0 °C(Predicted) | [density ]
1.28 | [storage temp. ]
−20°C
| [solubility ]
Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol | [form ]
Solid | [color ]
Off-White to Light Grey | [Stability:]
Moisture Sensitive | [InChI]
InChI=1/C21H21ClO5/c1-13-3-7-15(8-4-13)20(23)25-12-18-17(11-19(22)26-18)27-21(24)16-9-5-14(2)6-10-16/h3-10,17-19H,11-12H2,1-2H3/t17-,18+,19+/s3 | [InChIKey]
XJHDINDXQMZBKW-XUVXKRRUSA-N | [SMILES]
[C@@H]1(Cl)O[C@H](COC(=O)C2=CC=C(C)C=C2)[C@@H](OC(=O)C2=CC=C(C)C=C2)C1 |&1:0,3,15,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
Hoffer''s Chlorosugar is a synthetic precursor for ribose glycosides and ribonucleosides. | [Synthesis]
Under argon protection, (2R,3S)-5-methoxy-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate (50.0 g, 0.13 mol) was dissolved in glacial acetic acid (150 mL) and stirred at room temperature for 20 min. The reaction solution was cooled to 10-15 °C and a dioxane solution (150 mL, 0.6 mol) in 4 M HCl was slowly added dropwise for a controlled time of 5 min. After observing a light straw color to the solution, a small amount of 1-Α-chloro-3,5-di-O-tosyl-2-deoxy-D-ribofuranose crystal species was added and stirred briefly until a precipitate appeared. Stirring was stopped and the reaction mixture was allowed to stand for 40 minutes while being kept cool with an ice water bath. The white slurry was broken up by swirling the flask and quickly filtered. The resulting filter cake was washed with cold ether (3 x 30 mL) and dried under high vacuum to afford the target product 1-Α-chloro-3,5-di-O-p-toluoyl-2-deoxy-D-ribofuranose (34.1 g, 67% yield) as a white solid. The spectral data and analytical results of the product were in agreement with those reported in the literature. Thin layer chromatography (TLC) Rf value was 0.58 (Expanding agent: ethyl acetate-hexane, 1:2). Infrared spectra (IR, cm-1): 3030, 2951, 1708, 1276, 1178, 1099, 755. nuclear magnetic resonance hydrogen spectrum (1H NMR, 250.1 MHz, CDCl3): δ 2.41 (s, 3H, CH3), 2.42 (s, 3H, CH3), 2.74 (m, 1H, 2-CH), 2.84 (m 1H, 2-CH), 4.61 (dd, J=12.1,4.1 Hz, 1H, 5-CH), 4.66 (dd, J=12.1,4.1 Hz, 1H, 5-CH), 4.85 (m, 1H, 4-CH), 5.58 (m, 1H, 3-CH), 6.47 (d, J=4.2 Hz, 1H, 1-CH), 7.24 (d, J=8.3 Hz, 2H, 3,5-tol-CH), 7.26 (d, J=8.3 Hz, 2H, 3,5-tol-CH), 7.90 (d, J=8.3 Hz, 2H, 2,6-tol-CH), 7.99 (d, J=8.3 Hz, 2H, 2,6-tol-CH). Nuclear magnetic resonance carbon spectrum (13C NMR, 62.9 MHz, CDCl3): δ 21.70 (CH3), 21.71 (CH3), 44.54 (2-CH2), 63.51 (5-CH2), 73.56 (4-CH), 84.71 (3-CH), 95.3 (1-CH), 126.66 (C), 126.72 ( C), 129.19 (CH), 129.21 (CH), 129.63 (CH), 129.88 (CH), 144.07 (C), 144.30 (C), 166.07 (CO), 166.41 (CO). Mass spectra (EI): m/z (relative abundance) 353 ([M-Cl]+, 1), 252 (1), 216 (32), 136 (38), 119 (100), 91 (78), 81 (100), 65 (28), 53 (25), 39 (19). Calculated elemental analysis (C21H22ClO5): C, 64.8; H, 5.41. Measured values: C, 64.4; H, 5.39. | [References]
[1] Organic and Biomolecular Chemistry, 2003, vol. 1, # 13, p. 2267 - 2275
[2] Organic Letters, 2002, vol. 4, # 26, p. 4571 - 4574
[3] Journal of the Chinese Chemical Society, 1997, vol. 44, # 4, p. 413 - 416
[4] Arkivoc, 2017, vol. 2017, # 3, p. 87 - 104
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 2044 - 2050 |
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