| Chemical Properties | Back Directory | [Boiling point ]
689.8±55.0 °C(Predicted) | [density ]
1.244±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMSO: 20.83 mg/mL (47.49 mM) | [form ]
Oil | [pka]
16.93±0.30(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C24H30N4S2/c1-3-7-23-21(5-1)19(17-27-23)9-11-25-13-15-29-30-16-14-26-12-10-20-18-28-24-8-4-2-6-22(20)24/h1-8,17-18,25-28H,9-16H2 | [InChIKey]
AJBHTYKMNQDUAA-UHFFFAOYSA-N | [SMILES]
C(C1=CNC2=CC=CC=C21)CNCCSSCCNCCC1=CNC2=CC=CC=C12 |
| Hazard Information | Back Directory | [Uses]
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes[1][2]. | [Definition]
ChEBI: N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[2-(1H-indol-3-yl)ethan-1-amine] is an organic disulfide composed of two molecules of 2-{[2-(1H-indol-3-yl)ethyl]amino}ethane-1-thiol linked together via a disulfide bond. It is a glucose-6-phosphate dehydrogenase (G6PD) activator which reduces oxidative stress in cells and zebrafish. It is an organic disulfide, a member of indoles and a secondary amino compound. | [storage]
Store at -20°C,unstable in solution, ready to use. | [References]
[1] https://patents.google.com/patent/WO2019023264A1/en?oq=WO2019023264A1
[2] Kaitlyn Ryan, et al. Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency. Pharmacol Ther. 2020 Dec 14;222:107788. DOI:10.1016/j.pharmthera.2020.107788 |
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| Company Name: |
commedx Gold
|
| Tel: |
010-46598925 18519000250 |
| Website: |
www.commedx.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-8447131 13564518121 |
| Website: |
www.yuhua99.com/ShowSupplierProductsList927327/0_EN.htm |
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