| Identification | Back Directory | [Name]
2,4,6-Trimethylbenzylamine | [CAS]
40393-99-5 | [Synonyms]
MesitylMethanaMine
RARECHEM AL BW 0351
1-MESITYLMETHANAMINE
1-MESITYLMETHYLAMINE
2,4,6-Trimethylbenzy
1-MesitylMethanaMine, 97%+
2,4,6-TRIMETHYLBENZYLAMINE
2,4,6-Trimethylbenzylamine 97%
2,4,6-Trimethylbenzylamine,99%
2,4,6-TriMethylbenzylaMine, 99% 1GR | [Molecular Formula]
C10H15N | [MDL Number]
MFCD03411013 | [MOL File]
40393-99-5.mol | [Molecular Weight]
149.23 |
| Chemical Properties | Back Directory | [Appearance]
clear yellow liquid | [Melting point ]
196-197 °C | [Boiling point ]
98.5-100 °C(Press: 6 Torr) | [density ]
0.943±0.06 g/cm3(Predicted) | [refractive index ]
1.536-1.538
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Liquid | [pka]
9.58±0.10(Predicted) | [color ]
Clear yellow |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow liquid | [Synthesis Reference(s)]
Journal of the American Chemical Society, 78, p. 1653, 1956 DOI: 10.1021/ja01589a043 | [Synthesis]
A. Synthesis of 2,4,6-trimethylbenzylamine: To a solution of 2,4,6-trimethylbenzyl chloride (5 g, 29.7 mmol) in DMSO (20 mL) was added sodium azide (2.9 g, 44.6 mmol). The reaction mixture was heated at 60 °C with stirring for 3 h. After completion of the reaction, it was cooled to room temperature and poured into water (200 mL). The resulting precipitate was collected by filtration and dissolved in wet THF (50 mL) followed by the addition of triphenylphosphine (15.6 g, 59.4 mmol). The mixture was heated to reflux and maintained for 3 hours. At the end of the reaction, the volatiles were removed by evaporation. The residue was dissolved in 1N HCl (200 mL) and the insoluble material was removed by filtration. The filtrate was alkalized and the resulting precipitate was collected by filtration and finally dried under vacuum to give 2,4,6-trimethylbenzylamine (2.7 g, 61% yield). | [References]
[1] Patent: US6420567, 2002, B1
[2] Journal of the American Chemical Society, 1956, vol. 78, p. 1653,1656
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 22, p. 4485 - 4499 |
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