| Identification | Back Directory | [Name]
3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE | [CAS]
37804-11-8 | [Synonyms]
ACDPP HYDROCHLORIDE
3-amino-6-chloro-5-(dimethylamino)-N-2-pyridinyl-2-Pyrazinecarboxamide
3-AMINO-6-CHLORO-5-DIMETHYLAMINO-N-2-PYRIDINYLPYRAZINECARBOXAMIDE HYDROCHLORIDE | [Molecular Formula]
C12H14Cl2N6O | [MDL Number]
MFCD08703105 | [MOL File]
37804-11-8.mol | [Molecular Weight]
329.185 |
| Hazard Information | Back Directory | [Biological Activity]
Antagonist at the mGlu 5 receptor (K i = 295 nM). Inhibits human mGlu 5 receptor-mediated calcium flux with an IC 50 of 134 nM. | [Uses]
ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist)[1]. | [storage]
Desiccate at RT | [References]
[1] Wang H, et al. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28(17):4385-97. DOI:10.1523/JNEUROSCI.0646-08.2008 |
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