| Identification | Back Directory | [Name]
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA | [CAS]
37686-84-3 | [Synonyms]
TDHL
Teluron
dironyl
tergurid
terguride
S(+)-TERGURIDE
R-(+)-TERGURIDE
TRANS-DIHYDROLISURIDE
9,10a-Dihydrolisuride
Ergoline, urea deriv.
9,10α-Dihydrolisuride
(5R,8S,10R)-Terguride
(+)-(5R,8S,10R)-Terguride
9,10-alpha-dihydrolisuride
S(+)-TERGURIDE (5R, 8S, 10R)
Indolo[4,3-fg]quinoline, urea deriv.
1,1-Diethyl-3-(6-methylergolin-8α-yl)urea
6-Methyl-8a-(diethylcarbamoylamino)ergoline
6-Methyl-8α-(diethylcarbaMoylaMino)ergoline
N,N-Diethyl-N'-[(8α)-6-Methylergolin-8-yl]urea
Urea, N,N-diethyl-N'-[(8α)-6-methylergolin-8-yl]-
s(+)-n,n-diethyl-n'([8α]-6-methylergolin-8-yl)urea
N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea
n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)-ure
N,N-Diethyl-N'-(D-6-Methyl-10α-isoergolin-8-yl)urea
1-((5r,8s,10r)-6-methyl-8-ergolinyl)-3,3-diethylurea
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
Urea, N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- (9CI)
S(+)-N,N-Diethyl-Nμ([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R)
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea | [EINECS(EC#)]
253-624-2 | [Molecular Formula]
C20H28N4O | [MDL Number]
MFCD00242729 | [MOL File]
37686-84-3.mol | [Molecular Weight]
340.46 |
| Chemical Properties | Back Directory | [Melting point ]
203-204° (dec); mp 205-207° (dec) (Cerny) | [alpha ]
D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine) | [Boiling point ]
476.25°C (rough estimate) | [density ]
1.1056 (rough estimate) | [refractive index ]
1.6620 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble | [form ]
solid | [pka]
13.60±0.20(Predicted) | [color ]
white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3 | [Uses]
An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent. | [Definition]
ChEBI: Terguride is an organic molecular entity. | [in vivo]
TDHL abolished 5-HT-induced pulmonary vasoconstriction. Chronic terguride treatment prevented dose-dependently the development and progression of MCT-induced PAH in rats[1]. In reserpinized rats, terguride at 0.03 mg/kg, p.o. significantly reduces the serum prolactin (PRL) level. In rats bearing estrogen-induced pituitary prolactinoma, chronic terguride induces shrinkage of the prolactinoma as well as reduction of the high serum PRL level. In lactating rats, terguride (1.0 mg/kg, s.c.) reduces milk production in the mammary gland[2]. | [References]
1) Akai et al. (1993), Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507
2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215
3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104 |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Abcam Limited
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| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
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