| Identification | Back Directory | [Name]
2-AMINO-5-CHLOROBENZYL ALCOHOL | [CAS]
37585-25-4 | [Synonyms]
SKL307
37585-25-4
RARECHEM AL BD 1516
2-AMINO-5-CHLOROBENZYL ALCOHOL
2-Amino-5-chlorobenzenemethanol
(2-AMINO-5-CHLOROPHENYL)METHANOL
Benzenemethanol, 2-amino-5-chloro-
2-AMINO-5-CHLOROBENZYL ALCOHOL USP/EP/BP | [Molecular Formula]
C7H8ClNO | [MDL Number]
MFCD00075163 | [MOL File]
37585-25-4.mol | [Molecular Weight]
157.6 |
| Chemical Properties | Back Directory | [Melting point ]
107-109 °C(lit.)
| [Boiling point ]
320.7±27.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
13.94±0.10(Predicted) | [Appearance]
White to off-white Solid | [CAS DataBase Reference]
37585-25-4 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL PROCEDURE: A solution was prepared by dissolving 2-amino-5-chlorobenzoic acid (8.5 mmol) in THF (24 mL) at room temperature. This solution was added dropwise to a suspension of lithium aluminum hydride (20.4 mmol) in THF (10 mL) over 20 minutes. The reaction mixture was stirred continuously for 3.5 h at room temperature. Subsequently, water (10 mL) was added slowly at 0 °C to quench the reaction. The resulting suspension was filtered through a diatomaceous earth plug and washed with EtOAc (100 mL). The organic phase was washed with brine (30 mL), dried over anhydrous MgSO4 and finally concentrated under vacuum to give 2-amino-5-chlorobenzyl alcohol. | [References]
[1] ACS Catalysis, 2013, vol. 3, # 4, p. 622 - 624
[2] Organic Letters, 2017, vol. 19, # 12, p. 3219 - 3222
[3] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799
[4] Patent: WO2010/37533, 2010, A1. Location in patent: Page/Page column 44
[5] Organic Letters, 2016, vol. 18, # 21, p. 5572 - 5575 |
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Alfa Aesar
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