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ChemicalBook--->CAS DataBase List--->359600-10-5

359600-10-5

359600-10-5 Structure

359600-10-5 Structure
IdentificationBack Directory
[Name]

RNPA1000
[CAS]

359600-10-5
[Synonyms]

RNPA1000
Benzoic acid, 4-[3-[3-[(3-bromophenyl)amino]-2-cyano-3-oxo-1-propen-1-yl]-2,5-dimethyl-1H-pyrrol-1-yl]-
4-(3-{(1Z)-3-[(3-bromophenyl)amino]-2-cyano-3-oxoprop-1-en-1-yl}-2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid
[Molecular Formula]

C23H18BrN3O3
[MDL Number]

MFCD02611943
[MOL File]

359600-10-5.mol
[Molecular Weight]

464.31
Chemical PropertiesBack Directory
[Boiling point ]

692.3±55.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

3.74±0.10(Predicted)
[color ]

Light yellow to khaki
Hazard InformationBack Directory
[Description]

RNPA1000 is an inhibitor of growth of Staphylococcus aureus. It also acts as a RNase inhibitor.
[Uses]

RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity[1][2][3].
[References]

[1] Eidem TM, et al. Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus. J Biomater Appl. 2014 Apr;28(8):1235-46. DOI:10.1177/0885328213503388
[2] Eidem TM, et al. Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing. Antimicrob Agents Chemother. 2015 Apr;59(4):2016-28. DOI:10.1128/AAC.04352-14
[3] Patrick D Olson, et al. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog. 2011 Feb 10;7(2):e1001287. DOI:10.1371/journal.ppat.1001287
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