| Identification | Back Directory | [Name]
RNPA1000 | [CAS]
359600-10-5 | [Synonyms]
RNPA1000
Benzoic acid, 4-[3-[3-[(3-bromophenyl)amino]-2-cyano-3-oxo-1-propen-1-yl]-2,5-dimethyl-1H-pyrrol-1-yl]-
4-(3-{(1Z)-3-[(3-bromophenyl)amino]-2-cyano-3-oxoprop-1-en-1-yl}-2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid | [Molecular Formula]
C23H18BrN3O3 | [MDL Number]
MFCD02611943 | [MOL File]
359600-10-5.mol | [Molecular Weight]
464.31 |
| Chemical Properties | Back Directory | [Boiling point ]
692.3±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.74±0.10(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Description]
RNPA1000 is an inhibitor of growth of Staphylococcus aureus. It also acts as a RNase inhibitor. | [Uses]
RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity[1][2][3]. | [References]
[1] Eidem TM, et al. Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus. J Biomater Appl. 2014 Apr;28(8):1235-46. DOI:10.1177/0885328213503388
[2] Eidem TM, et al. Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing. Antimicrob Agents Chemother. 2015 Apr;59(4):2016-28. DOI:10.1128/AAC.04352-14
[3] Patrick D Olson, et al. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog. 2011 Feb 10;7(2):e1001287. DOI:10.1371/journal.ppat.1001287 |
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Musechem
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www.musechem.com |
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BOC Sciences
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www.bocsci.com |
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