| Identification | Back Directory | [Name]
2(4-biphenyl)propionic acid | [CAS]
35888-99-4 | [Synonyms]
Biphenyl-4-propanoic acid
2(4-biphenyl)propionic acid
3-(4-Biphenyl)propanic acid
3-biphenyl-4-ylpropanoic acid
2(para-biphenyl)propionic acid
3-(4-Biphenylyl)propionic acid
1,1'-Biphenyl]-4-propanoic acid
3-(4-Biphenyl)propionicacid,98%
3-(4-phenylphenyl)propionic acid
(1,1'-Biphenyl)-4-propanoic acid
3-([1,1'-biphenyl]-4-yl)propanoic acid | [Molecular Formula]
C15H14O2 | [MDL Number]
MFCD06823979 | [MOL File]
35888-99-4.mol | [Molecular Weight]
226.27 |
| Chemical Properties | Back Directory | [Melting point ]
149-152℃ | [Boiling point ]
400.4±24.0 °C(Predicted) | [density ]
1.138±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.65±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
3-(4-Biphenyl)propionic Acid is a reactant in the preparation of 1,3,4-oxadiazole containing histone deacetylase inhibitors with anticancer activity. | [Synthesis]
GENERAL METHOD: Ester compounds 2a, c-f, i-1, o-p, w (1.35 mmol, 1.0 eq.) were dissolved in dioxane (at a concentration of 0.15 mmol/mL), followed by the addition of 5 M aqueous NaOH (10.0 eq.). The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was acidified, extracted with ethyl acetate (EtOAc), the organic phase was dried with anhydrous magnesium sulfate (MgSO4), and finally concentrated under vacuum to give carboxylic acid analogs 3a, c-f, i-1, o-p, and w as solids. | [References]
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 4013 - 4025 |
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