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ChemicalBook--->CAS DataBase List--->35882-85-0

35882-85-0

35882-85-0 Structure

35882-85-0 Structure
IdentificationBack Directory
[Name]

26,27-Dinorergost-5-ene-3β,24-diol
[CAS]

35882-85-0
[Synonyms]

SGE-201
26,27-Dinorergost-5-ene-3β,24-diol
24,24-dimethyl-cholene-(5)-diol-(3β.24)
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-5-methylhexan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
[Molecular Formula]

C26H44O2
[MDL Number]

MFCD28386299
[MOL File]

35882-85-0.mol
[Molecular Weight]

388.63
Chemical PropertiesBack Directory
[Boiling point ]

501.1±23.0 °C(Predicted)
[density ]

1.04±0.1 g/cm3(Predicted)
[pka]

15.03±0.70(Predicted)
Hazard InformationBack Directory
[Description]

SGE-201 is a potent allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 is an analogue of an endogenous oxysterol. bSGE-201 increased the actions of memantine and ketamine on phasic excitatory post-synaptic currents, but neither revealed underlying pharmacodynamic differences. SGE-201 accelerated the re-equilibration of blockers during voltage jumps. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult.
[Uses]

SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors (NMDARs), demonstrating significant neuroprotective effects by enhancing NMDAR-mediated responses while differing in action among various blockers in neuronal networks.
[References]

[1] The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors DOI:10.1523/JNEUROSCI.2619-13.2013
35882-85-0 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: SPIRO PHARMA  
Tel:
Website: www.spiropharma.com.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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