| Identification | Back Directory | [Name]
negamycin | [CAS]
33404-78-3 | [Synonyms]
negamycin
(3R,5R)-3,6-Diamino-5-hydroxyhexanoic acid 2-(carboxymethyl)-2-methyl hydrazide
(3R,5R)-3,6-Diamino-5-hydroxyhexanoic acid-N'-methyl-N'-(2-oxo-2-hydroxyethyl) hydrazide
L-threo-Hexonic acid, 3,6-diamino-2,3,4,6-tetradeoxy-, 2-(carboxymethyl)-2-methylhydrazide | [Molecular Formula]
C9H20N4O4 | [MDL Number]
MFCD01672022 | [MOL File]
33404-78-3.mol | [Molecular Weight]
248.28 |
| Chemical Properties | Back Directory | [Melting point ]
110-120° (dec) | [alpha ]
D29 +2.5° (c = 2) | [density ]
1.303±0.06 g/cm3(Predicted) | [pka]
pKa values after treatment with HCl-methanol: 3.55, 8.10, 9.75(at 25℃) |
| Hazard Information | Back Directory | [Uses]
Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons. | [References]
[1] Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome DOI:10.1073/pnas.1414401111 |
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