| Identification | Back Directory | [Name]
Tesetaxel | [CAS]
333754-36-2 | [Synonyms]
DJ 927
Tesetaxel
2-Pyridinepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-3-fluoro-α-hydroxy-, (2aS,2bR,3S,4S,6S,8aR,10S,11aS,11bR,13aR)-2a-(acetyloxy)-3-(benzoyloxy)-10-[(dimethylamino)methyl]-2a,2b,3,4,5,6,8a,11a,11b,12,13,13a-dodecahydro-4-hydroxy-7,11b,14,14-tetramethyl-4,8-methano-2H-oxeto[3'',2'':3',4... | [Molecular Formula]
C46H60FN3O13 | [MDL Number]
MFCD22572781 | [MOL File]
333754-36-2.mol | [Molecular Weight]
881.99 |
| Hazard Information | Back Directory | [Uses]
Tesetaxel is a orally active, semisynthetic microtubule inhibitor of the taxane class for the research of cancer, including colorectal and gastric cancer. | [References]
[1] Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci. 2003;94(5):459-466. DOI:10.1111/j.1349-7006.2003.tb01465.x
[2] Saif MW, Sarantopoulos J, Patnaik A, Tolcher AW, Takimoto C, Beeram M. Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2011;68(6):1565-1573. DOI:10.1007/s00280-011-1639-3 |
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