| Identification | Back Directory | [Name]
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide | [CAS]
332117-28-9 | [Synonyms]
CS-1651
TCS 5861528
CheMbridge 5861528
TCS 5861528;TCS-5861528;TCS5861528
CHEMBRIDGE-5861528;TCS-5861528;TCS5861528
7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide | [Molecular Formula]
C19H23N5O3 | [MDL Number]
MFCD01993436 | [MOL File]
332117-28-9.mol | [Molecular Weight]
369.42 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO : 74 mg/mL (200.31 mM; Need ultrasonic and warming) | [form ]
Powder | [pka]
13.75±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TCS 5861528 is a TRPA1 channel antagonist, which may prevent development of diabetic hypersensitivity. | [in vivo]
Chembridge-5861528 (TCS 5861528) (30 mg/kg; i.p.; twice daily for a week) significantly attenuates development of mechanical hypersensitivity in Streptozocin (HY-13753)-induced diabetes mellitus rat model[1].
Chembridge-5861528 (3 and 10 μg/rat; i.t.; once) attenuates Capsaicin.html" class="link-product" target="_blank">Capsaicin (HY-10448)-induced blood flow increase in a dose-related fashion[2]. | Animal Model: | Male Hannover-Wistar rats, Streptozocin-induced diabetes mellitus model[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection, twice daily for a week | | Result: | Significantly attenuated development of mechanical hypersensitivity as revealed by the paw pressure test (F1,80= 31.4, P < 0.0001). |
| Animal Model: | Male Hannover–Wistar rats (220-260 g), Capsaicin-induced neurogenic inflammation model[2] | | Dosage: | 0, 3, and 10 μg/rat | | Administration: | Intrathecal injection, 20 min before Capsaicin injection | | Result: | Significantly decreased the blood flow at 10 μg. |
| [IC 50]
TRPA1: 14.3 μM (IC50, allyl isothiocyanate-evoked TRPA1 response); TRPA1: 18.7 μM (IC50, 4-HNE-evoked TRPA1 response) | [storage]
Store at RT |
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