| Identification | Back Directory | [Name]
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) | [CAS]
330681-18-0 | [Synonyms]
(3R,4R)-3-Amino-1-Boc-4-hydroxypyrrolidine
(3R,4R)-4-aMino-1-N-Boc-3-hydroxypyrrolidine
Trans-(3R,4R)-1-Boc-3-aMino-4-hydroxypyrrolidine
rel-tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
1-Pyrrolidinecarboxylic acid, 3-amino-4-hydroxy-, 1,1-dimethylethyl ester, (3R,4R)-
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) USP/EP/BP | [Molecular Formula]
C9H18N2O3 | [MDL Number]
MFCD11111251 | [MOL File]
330681-18-0.mol | [Molecular Weight]
202.25 |
| Chemical Properties | Back Directory | [Boiling point ]
308.8±42.0 °C(Predicted) | [density ]
1.179 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
14.36±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of tert-butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate from the compound (CAS:1202067-36-4): trifluoroacetic acid (3 drops) was added to a solution of intermediate 19 (2.5 g, 8.4 mmol) in methanol (50 mL), and the reaction mixture was stirred for 2 hours. Subsequently, platinum oxide (100 mg, 0.44 mmol) was added to the reaction system and stirring was continued for 18 hours under hydrogen atmosphere. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the solvent was removed by evaporation under vacuum. The resulting crude product was purified by recrystallization from dichloromethane to afford the target product (3R,4R)-tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate as a white solid (1.5 g, 89% yield). NMR hydrogen spectrum (CDCl3) data: δ 3.99 (1H, m), 3.70 (2H, m), 3.34 (2H, m), 3.12 (1H, m), 1.48 (9H, s). | [References]
[1] Patent: WO2009/153554, 2009, A1. Location in patent: Page/Page column 43 |
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