| Identification | Back Directory | [Name]
7(8H)-Pteridinone, 8-cyclopentyl-2-[[4-(1-piperazinyl)phenyl]amino]- | [CAS]
330550-51-1 | [Synonyms]
7(8H)-Pteridinone, 8-cyclopentyl-2-[[4-(1-piperazinyl)phenyl]amino]- | [Molecular Formula]
C21H25N7O | [MOL File]
330550-51-1.mol | [Molecular Weight]
391.47 |
| Hazard Information | Back Directory | [Uses]
YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1 (HY-163786)[1]. | [IC 50]
CDK4: 7.7 nM (IC50); CDK6: 88 nM (IC50) | [References]
[1] He H, et al., Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design. J Med Chem. 2024 Jul 11;67(13):11354-11364. DOI:10.1021/acs.jmedchem.4c00965 |
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