| Identification | Back Directory | [Name]
BOC-HIS(TOS)-MERRIFIELD RESIN | [CAS]
33018-91-6 | [Synonyms]
2-ethylheptanedioate
MonoethylPimelate>
BOC-HIS(TOS)-CMS RESIN
BOC-HIS(TOS)-PAM RESIN
BOC-HIS(TOS)-BHA RESIN
Monoethyl Heptanedioate
Ethyl hydrogen pimelate
BOC-HIS(TOS)-MBHA RESIN
pimelicacidmonethylester
BOC-L-HIS(TOS)-MBHA RESIN
PAM BOC-L-HISTIDINE (TOS)
BOC-HIS(TOS)-BHA PS RESIN
BOC-HIS(TOS)-MBHA PS RESIN
Ethyl hydrogen pimelate-98%
7-ethoxy-7-oxoheptanoic acid
Pimelic acid monomethyl ester
BOC-HIS(TOS)-MERRIFIELD RESIN
Heptanedioic acid 1-ethyl ester
BOC-HIS(TOS)-MERRIFIELD PS RESIN
PAM TBOC-L-HISTIDINE (TOS) RESIN
ethyl hydrogen heptane-1,7-dioate
heptanedioic acid monoethyl ester
Pimelic acid 1-hydrogen 7-ethyl ester
Ethylhydrogenpimelate,(Monoethylpimelate
BOC-NIM-TOSYL-L-HISTIDINE-MERRIFIELD RESIN
BOC-HIS(TOS)-PAM-PHENYL-ACETAMIDOMETHYL-RESIN
BOC-HIS(TOS)-MERRIFIELD RESIN ISO 9001：2015 REACH
N-ALPHA-BOC-NIM-TOSYL-L-HISTIDINE-MERRIFIELD RESIN
PHENYLACETAMIDOMETHYL TBOC-L-HISTIDINE (TOS) RESIN
Ethyl Hydrogen Pimelate
Pimelic Acid Monoethyl Ester
NALPHA-BOC-N(IM)-TOSYL-L-HISTIDINE BOUND TO PAM RESIN
BOC-N-IM-4-TOLUENESULFONYL-L-HISTIDINE MERRIFIELD RESIN
BOC-N-IM-4-TOLUENESULFONYL-L-HISTIDINE BENZHYDRYLAMINE RESIN
BOC-NIM-TOSYL-L-HISTIDINE-4-(OXYMETHYL)-PHENYLACETAMIDOMETHYL RESIN
N-BOC-N-TOSYL-L-HISTIDINE-4-(OXYMETHYL)-PHENYLACETAMIDOMETHYL RESIN
BOC-N-IM-4-TOLUENESULFONYL-L-HISTIDINE 4-METHYLBENZHYDRYLAMINE RESIN
N-ALPHA-BOC-NIM-TOSYL-L-HISTIDINE-4-(OXYMETHYL)-PHENYLACETAMIDOMETHYL RESIN
N-Alpha-T-Butoxycarbonyl-N-Im-Tosyl-L-Histidine-P-Hydroxymethyl Phenylacet
BOC-N-IM-4-TOLUENESYLFONYL-L-HISTIDINE 4-OXYMETHYLPHENYLACETAMIDOMETHYL RESIN
Heptanedioic acid monoethyl ester~Monoethyl pimelate~Pimelic acid monoethyl ester
N-ALPHA-T-BUTOXYCARBONYL-N-IM-TOSYL-L-HISTIDINE-P-HYDROXYMETHYL PHENYLACETOAMIDOMETHYL POLYSTYRENE | [EINECS(EC#)]
251-346-6 | [Molecular Formula]
C9H16O4 | [MDL Number]
MFCD00801202 | [MOL File]
33018-91-6.mol | [Molecular Weight]
188.22 |
| Chemical Properties | Back Directory | [Melting point ]
10°C | [Boiling point ]
135-138°C 1mm | [density ]
1.06 | [refractive index ]
1.4420 | [Fp ]
135-138°C/1mm | [storage temp. ]
2-8°C
| [form ]
powder to lump to clear liquid | [pka]
4.74±0.10(Predicted) | [color ]
White or Colorless to Almost white or Almost colorless | [Water Solubility ]
Not miscible or difficult to mix with water. | [BRN ]
1774583 | [InChI]
InChI=1S/C9H16O4/c1-2-13-9(12)7-5-3-4-6-8(10)11/h2-7H2,1H3,(H,10,11) | [InChIKey]
NQYXFXWKKYGBNL-UHFFFAOYSA-N | [SMILES]
C(OCC)(=O)CCCCCC(O)=O | [CAS DataBase Reference]
33018-91-6 |
| Hazard Information | Back Directory | [Uses]
Ethyl hydrogen pimelate is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. | [Synthesis]
3) Synthesis of 7-ethoxy-7-oxoheptanoic acid: potassium hydroxide (KOH, 16.8 g, 0.30 mol) was added to a solution of diethyl heptanedioate (65 g, 0.30 mol) in ethanol (400 mL). The reaction mixture was stirred at 80 °C for 24 h. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The concentrated mixture was poured into water and the pH of the aqueous solution was adjusted with concentrated sulfuric acid (H2SO4) to 1. The aqueous phase was extracted and the organic solvent was removed to give the crude product. The crude product was purified by fast column chromatography (silica gel SiO2 as stationary phase, eluent ratio of ethanol:ethyl acetate=1:10), and finally 7-ethoxy-7-oxoheptanoic acid was obtained (38 g, 67% yield). | [References]
[1] Patent: US2014/256775, 2014, A1. Location in patent: Paragraph 0178; 0183; 0184
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 9, p. 2776 - 2785
[3] Bulletin de la Societe Chimique de France, 1910, vol. <4>7, p. 219
[4] Journal of the Chemical Society, 1901, vol. 79, p. 1192
[5] Bioorganic Chemistry, 1998, vol. 26, # 3, p. 157 - 168 |
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