| Identification | Back Directory | [Name]
ICA 110381 | [CAS]
325457-99-6 | [Synonyms]
ICA-11038
ICA 110381
ICA 110381; ICA110381
ICA 110381 (Compound 16)
4-CHLOR-N-(6-CHLOR-PYRIDIN-3-YL)-BENZAMID
4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
4-Chloro-N-(6-chloro-pyridin-3-yl)-benzamide | [Molecular Formula]
C12H8Cl2N2O | [MDL Number]
MFCD05669575 | [MOL File]
325457-99-6.mol | [Molecular Weight]
267.11 |
| Chemical Properties | Back Directory | [Boiling point ]
336.8±37.0 °C(Predicted) | [density ]
1.440±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml). | [form ]
solid | [pka]
11.34±0.70(Predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM).1?KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity?in vivo.2 | [Uses]
ICA 110381 was used to study the pharmacological activities as it selectively activated human KCNQ2 expressed in Chinese hamster ovary, damped neuronal excitability in rat hippocampal CA1 cell and showed anticonvulsant activity in amygdala-kindled rat. | [in vivo]
ICA 110381 (3-30 mg/kg; p.o.; once) elevates the threshold for induction of afterdischarges and reduced seizure severity and duration in fully amygdala-kindled rats[2]. | Animal Model: | Female Wistar rats (200-300 g)[2] | | Dosage: | 3 mg/kg, 10 mg/kg and 30 mg/kg (suspended in 0.5% Hydroxyethyl Cellulose (HY-B2221B)) | | Administration: | Oral administration; once | | Result: | Showed anticonvulsive properties in fully amygdala-kindled rats. |
| [IC 50]
KV7.1: 0.38 μM (EC50); KV7.3: 0.38 μM (EC50); KV7.1: 15 μM (IC50) | [storage]
Store at +4°C | [References]
1) Amato?et al. (2011),?N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett.,?2?481
2) Boehlen?et al. (2013),?The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol.,?168?1182 |
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| Company Name: |
Atomic chemistry
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| Tel: |
0370-2785705 17550096163 |
| Website: |
www.yuanzichem.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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