| Identification | Back Directory | [Name]
AC-VEID-CHO | [CAS]
319494-39-8 | [Synonyms]
AC-VEID-CHO
AC-VEID-ALDEHYDE
CASPASE-6 INHIBITOR II
AC-VAL-GLU-ILE-ASP-CHO
VEID-CHO, CELL-PERMEABLE
N-Acetyl-Val-Glu-Ile-Asp-al
AC-VAL-GLU-ILE-ASP-ALDEHYDE
CASPASE 6 (MCH 2) INHIBITOR 1
CASPASE-6 INHIBITOR (ALDEHYDE)
N-ACETYL-VAL-GLU-ILE-ASPARTINAL
AC-VAL-GLU-ILE-ASP-H (ALDEHYDE)
Ac-VEID-CHO trifluoroacetate salt
CASPASE-6 INHIBITOR II, CELL-PERMEABLE
N-ACETYL-VAL-GLU-ILE-ASP-CHO (ALDEHYDE)
AC-VAL-GLU-ILE-ASP-ALDEHYDE (PSEUDO ACID)
ACETYL-L-VALYL-L-GLUTAMYL-L-ISOLEUCYL-L-ASPART-1-AL
L-Isoleucinamide, N-acetyl-L-valyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- | [Molecular Formula]
C22H36N4O9 | [MDL Number]
MFCD01318861 | [MOL File]
319494-39-8.mol | [Molecular Weight]
500.54 |
| Chemical Properties | Back Directory | [Boiling point ]
914.6±65.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
H2O: 1 mg/mL | [form ]
powder | [pka]
4.20±0.10(Predicted) | [color ]
white | [Water Solubility ]
H2O: 1mg/mL |
| Hazard Information | Back Directory | [Uses]
AC-VEID-CHO is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO also inhibits VEIDase activity an IC50 value of 0.49 μM. AC-VEID-CHO can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
caspase-6''Product does not compete with ATP.''Reversible: yes | [IC 50]
Caspase 3: 13.6 nM (IC50); Caspase-6: 16.2 nM (IC50); Caspase-7: 162.1 nM (IC50) | [References]
[1] Robert Mintzer, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012;7(1):e30376. DOI:10.1371/journal.pone.0030376 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
|