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ChemicalBook--->CAS DataBase List--->319494-38-7

319494-38-7

319494-38-7 Structure

319494-38-7 Structure
IdentificationBack Directory
[Name]

AC-LEHD-CHO
[CAS]

319494-38-7
[Synonyms]

AC-LEHD-CHO
AC-LEHD-ALDEHYDE
AC-LEU-GLU-HIS-ASP-CHO
AC-LEU-GLU-HIS-ASP-ALDEHYDE
N-Acetyl-Leu-Glu-His-Asp-al
CASPASE-9 INHIBITOR (ALDEHYDE)
N-ACETYL-LEU-GLU-HIS-ASP-CHO (ALDEHYDE)
Ac-Leu-Glu-His-Asp-aldehyde (pseudo acid) trifluoroacetate salt
L-Histidinamide, N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
N-Acetyl-L-leucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl ]-L-histidinamide
N-Acetyl-L-leucyl-L-alpha-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-histidinamide
[Molecular Formula]

C23H34N6O9
[MDL Number]

MFCD01862665
[MOL File]

319494-38-7.mol
[Molecular Weight]

538.55
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[form ]

Lyophilized Powder
[color ]

White to off-white
[Sequence]

Ac-Leu-Glu-His-Asp-CHO
Hazard InformationBack Directory
[Uses]

Ac-LEHD-CHO is an inhibitor for caspase 8/9. Ac-LEHD-CHO prevents GalN/TNF-α-induced hepatotoxicity and hepatocyte apoptosis[1].
[References]

[1] Kermer P, et al., Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo. Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):144-50. DOI:10.1016/s0169-328x(00)00256-4
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