| Identification | Back Directory | [Name]
GAK inhibitor 49 | [CAS]
319492-82-5 | [Synonyms]
GAK inhibitor 49
4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C20H22N2O5 | [MDL Number]
MFCD29701419 | [MOL File]
319492-82-5.mol | [Molecular Weight]
370.4 |
| Chemical Properties | Back Directory | [Boiling point ]
494.8±45.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (134.99 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
7?+-.0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1]. | [References]
[1] Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66. DOI:10.1002/cmdc.201700663 |
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