| Identification | Back Directory | [Name]
Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]- | [CAS]
313526-24-8 | [Synonyms]
IBR2
IBR2
(IBR 2)
RAD51,Apoptosis,IBR-2,IBR2,inhibit,Inhibitor,IBR 2
2-(Benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline
Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]- | [Molecular Formula]
C24H20N2O2S | [MDL Number]
MFCD00991660 | [MOL File]
313526-24-8.mol | [Molecular Weight]
400.49 |
| Chemical Properties | Back Directory | [Boiling point ]
651.2±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 150 mg/mL (374.54 mM) | [form ]
Solid | [pka]
16.67±0.30(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1][2]. | [storage]
Store at -20°C | [References]
[1] Jiewen Zhu, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5(3):353-65. DOI:10.1002/emmm.201201760
[2] Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208. DOI:10.1016/j.ejmech.2015.04.021 |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|