| Identification | Back Directory | [Name]
5-Methyl-1,3,4-oxadiazol-2(3H)-one | [CAS]
3069-67-8 | [Synonyms]
5-Methyl-1,3,4-oxadiazol-2(3H)-one
5-Methyl-2,3-dihydro-1,3,4-oxadiazol-2-one
2,3-dihydro-5-Methyl-2-oxo-1,3,4-oxadiazole
5-methyl-1,3,4-oxadiazol-2-ol(SALTDATA: FREE) | [Molecular Formula]
C3H4N2O2 | [MDL Number]
MFCD15143213 | [MOL File]
3069-67-8.mol | [Molecular Weight]
100.08 |
| Chemical Properties | Back Directory | [Melting point ]
112 °C | [Boiling point ]
134 °C(Press: 14 Torr) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
6.34±0.70(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
(2) Preparation of 5-methyl-1,3,4-oxadiazolone: 2000 mL of methyl acetate was added to a 5000 mL three-necked flask and 740 g of acetylhydrazine was added slowly under stirring conditions. The reaction mixture was cooled to below 0 °C, followed by the addition of 1680 g of sodium bicarbonate in batches. The reaction unit was sealed and the phosgene was continuously vented at a flow rate of 15 m3/h. After completion of the reaction, the solvent was removed by distillation and the resulting residue was crystallized at 0 °C. The white crystals were collected by filtration to give 988.2 g of the target product in 99% yield. | [References]
[1] Patent: CN103724327, 2017, B. Location in patent: Paragraph 0008; 0030; 0032 |
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