| Identification | Back Directory | [Name]
α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine | [CAS]
305372-78-5 | [Synonyms]
CCT036477
Wnt Pathway Inhibitor XI, CCT036477
N-((4-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine
α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
1H-Indole-3-methanamine, α-(4-chlorophenyl)-2-methyl-N-2-pyridinyl- | [Molecular Formula]
C21H18ClN3 | [MDL Number]
MFCD01831143 | [MOL File]
305372-78-5.mol | [Molecular Weight]
347.84 |
| Chemical Properties | Back Directory | [Melting point ]
>167°C (dec.) | [Boiling point ]
546.0±45.0 °C(Predicted) | [density ]
1.301±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: ≥20mg/mL (warm to 60°C) | [form ]
powder | [pka]
17.33±0.30(Predicted) | [color ]
white to tan | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes. | [Definition]
ChEBI: N-[(4-chlorophenyl)-(2-methyl-1H-indol-3-yl)methyl]-2-pyridinamine is a member of indoles. | [Biological Activity]
CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivoblocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes. |
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Struchem Co., Ltd.
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0512-0512-63009836 15365350169 |
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http://www.struchem.com |
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Energy Chemical
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http://www.energy-chemical.com |
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Merck Millipore
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www.merckmillipore.com |
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Enzo Biochem Inc
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Enzo Biochem Inc. 13797054060 |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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