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ChemicalBook--->CAS DataBase List--->3040999-70-7

3040999-70-7

3040999-70-7 Structure

3040999-70-7 Structure
IdentificationBack Directory
[Name]

Acetamide, N-[trans-4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]cyclohexyl]-
[CAS]

3040999-70-7
[Synonyms]

CDK7-IN-30
Acetamide, N-[trans-4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]cyclohexyl]-
[Molecular Formula]

C21H28ClN5O3S
[MOL File]

3040999-70-7.mol
[Molecular Weight]

466
Chemical PropertiesBack Directory
[density ]

1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

15.92±0.40(predicted)
Hazard InformationBack Directory
[Uses]

CDK7-IN-30 (Compound 22) is a CDK7 inhibitor (IC50 = 7.21 nM) that effectively inhibits the phosphorylation of RNA Polymerase II and CDK2. CDK7-IN-30 CDK7-IN-30 can induce cell apoptosis and has anti-cancer activity and can be used in cancer research[1].
[IC 50]

CDK7: 7.21 nM (IC50); CDK9: 704.3 nM (IC50); CDK1: >10000.00 nM (IC50); CDK2: 734.55 nM (IC50); CDK3: 370.40 nM (IC50); CDK4: 644.80 nM (IC50); CDK5: 3678.50 nM (IC50); CDK6: 1345.50 nM (IC50)
[References]

[1] Zhang H, et al. Design, Synthesis, and Biological Evaluation of 2, 4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2024.
3040999-70-7 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
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