Identification | Back Directory | [Name]
Acetamide, N-[trans-4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]cyclohexyl]- | [CAS]
3040999-70-7 | [Synonyms]
CDK7-IN-30 Acetamide, N-[trans-4-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]cyclohexyl]- | [Molecular Formula]
C21H28ClN5O3S | [MOL File]
3040999-70-7.mol | [Molecular Weight]
466 |
Hazard Information | Back Directory | [Uses]
CDK7-IN-30 (Compound 22) is a CDK7 inhibitor (IC50 = 7.21 nM) that effectively inhibits the phosphorylation of RNA Polymerase II and CDK2. CDK7-IN-30 CDK7-IN-30 can induce cell apoptosis and has anti-cancer activity and can be used in cancer research[1]. | [IC 50]
CDK7: 7.21 nM (IC50); CDK9: 704.3 nM (IC50); CDK1: >10000.00 nM (IC50); CDK2: 734.55 nM (IC50); CDK3: 370.40 nM (IC50); CDK4: 644.80 nM (IC50); CDK5: 3678.50 nM (IC50); CDK6: 1345.50 nM (IC50) | [References]
[1] Zhang H, et al. Design, Synthesis, and Biological Evaluation of 2, 4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2024. |
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