Identification | Back Directory | [Name]
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- | [CAS]
3032451-58-1 | [Synonyms]
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- | [Molecular Formula]
C26H21FN6O3 | [MOL File]
3032451-58-1.mol | [Molecular Weight]
484.48 |
Hazard Information | Back Directory | [Uses]
PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice[1]. | [IC 50]
PARP-1: 0.2235 nM (IC50) | [References]
[1] Yang Chun, et al., Phthalazinone or quinazolinone derivatives, pharmaceutical compositions and uses thereof. CN118324766A |
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